PWWP: PWWP domain
| PAG Title | PWWP: PWWP domain |
| PAG ID | PEX000515 |
| Type | A |
| Source Link |  Pfam |
| Publication Reference | NA |
| PAG Description | The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif 1. The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyses all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organising higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression 2. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 126 |
| Information Content | Rich |
| Other IDs | PF00855 |
| Base PAG ID | PEX000515 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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